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Study Finds COVID Boosters Don’t Increase Miscarriage Risk

COVID-19 boosters are not linked to an increased chance of miscarriage, according to a new study in  JAMA Network Open.

Researchers were seeking to learn whether a booster in early pregnancy, before 20 weeks, was associated with greater likelihood of spontaneous abortion.

They examined more than 100,000 pregnancies at 6 to 19 weeks from eight health systems in the Vaccine Safety Datalink (VSD). They found that receiving a COVID-19 booster shot in a 28-day or 42-day exposure window did not increase the chances of miscarriage.

“These findings support the safety of COVID-19 booster vaccination in early pregnancy,” they wrote.

The VSD is a collaboration between the CDC’s Immunization Safety Office and large health care systems. The “observational, case-control, surveillance study” was conducted from Nov. 1, 2021, to June 12, 2022.

“COVID infection during pregnancy increases risk of poor outcomes, yet many people who are pregnant or thinking about getting pregnant are hesitant to get a booster dose because of questions about safety,” said Elyse Kharbanda, MD, senior investigator at HealthPartners Institute and lead author of the study in a press release.

The University of Minnesota reported that, “Previous studies have shown COIVD-19 primary vaccination is safe in pregnancy and not associated with an increased risk for miscarriage. Several studies have also shown COVID-19 can be more severe in pregnancy and lead to worse outcomes for the mother.”


JAMA Network Open: “COVID-19 Booster Vaccination in Early Pregnancy and Surveillance for Spontaneous Abortion”

HealthPartners Institute: “New study finds COVID-19 mRNA booster vaccinations in early pregnancy did not increase miscarriage risk”

University of Minnesota: “COVID-19 boosters not linked to miscarriages”

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