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Pheochromocytoma Imaging


In 1912, a pathologist named Pick coined the term pheochromocytoma —after the Greek words phaios, meaning dark or dusky, and chroma, meaning color—to describe the chromaffin reaction seen in adrenomedullary tumors. The tumors arise from the chromaffin cells of the adrenal medulla and are associated with increased catecholamine production. Although chromaffin tissue is also present elsewhere in the body, such as in the mediastinum, along the aorta, and in the pelvis, the term pheochromocytoma is reserved for tumors that arise from the adrenal medulla. Chromaffin cell tumors at other locations are more appropriately called paragangliomas or chemodectomas, although the term extra-adrenal pheochromocytoma is still applied.
(Examples of pheochromocytomas are shown below.)

Patients with sporadic pheochromocytoma present at a mean age of approximately 44 years, and those with a genetic predisposition present at about 25 years of age.
Annual incidence is reported to be 2-8 per million and prevalence 0.05–0.12%.

Preferred imaging modalities

Patients who may be referred for imaging of the adrenal glands include those with new or worsening diabetes mellitus (owing to impaired glucose regulation) and those with hypertensive crisis after anesthesia, surgery, or treatment with medications. Imaging may also be performed in patients with a known history of multiple endocrine problems.

Computed tomography (CT) scanning and magnetic resonance imaging (MRI) have higher sensitivity in detecting pheochromocytomas than nuclear medicine scanning with iodine-131 metaiodobenzylguanidine  (131I-MIBG), although 131I-MIBG uptake is more specific. Some authors prefer to use MIBG uptake scanning as the initial screening modality because it enables whole-body imaging, making it useful for the detection of extra-adrenal tumors and metastatic deposits.

Once an adrenal or extra-adrenal tumor is detected, CT scanning or MRI of the region may be performed for anatomic localization prior to surgical removal. If 131I-MIBG uptake is negative but the clinical findings suggest pheochromocytoma, CT scanning or MRI of the chest or abdomen may be performed, because the false-negative rate of MIBG scintigraphy is 10%.

Luster et al investigated the specificity and sensitivity of (18)F-3,4-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) scanning, CT scanning, and a combination of the 2 modalities in the identification and localization of adrenal and extra-adrenal pheochromocytomas. Nineteen lesions were detected by all 3 imaging methods, but only DOPA PET/CT scanning accurately characterized and localized them all, demonstrating, on a per-patient basis, a sensitivity of 100% and a specificity of 88%.

A further study by Gaertner et al concluded the (18)F-LMI1195 is a promising tracer for tumor imaging.
Saad et al found in a study of 23 patients with a history of pheochromocytoma/paraganglioma that (18)F-FDG PET/CT was a superior tool for the localization of recurrent tumors.

Nonenhanced computed tomography (CT) scan in a 35-

Nonenhanced computed tomography (CT) scan in a 35-year-old woman with hypertension demonstrates a large, right-sided, inhomogeneous adrenal mass (white arrows) with a central area of low attenuation that represents hemorrhage or necrosis. The upper pole of the displaced right kidney can be seen (black arrow). Courtesy of Dr Ali Shirkhoda, William Beaumont Hospital, Michigan.

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Axial gradient-recalled magnetic resonance angiogr

Axial gradient-recalled magnetic resonance angiogram in a 42-year-old woman with a 5-year history of hypertension who underwent magnetic resonance angiography for the assessment of renal arterial stenosis. Although the renal arteries were unremarkable, a 7.5-cm X 5-cm right adrenal mass was incidentally identified. Angiogram demonstrates a large, right-sided, inhomogeneous adrenal mass (arrows). Courtesy of Dr Ali Shirkhoda, William Beaumont Hospital, Michigan.

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Detecting the tumors is important for a number of reasons. First, hypertension is usually cured with the removal of the tumor, whereas untreated patients are at risk for a lethal hypertensive paroxysm and long-term sequelae of the disease. Second, the discovery of a pheochromocytoma may indicate the presence of a familial disorder. Third, approximately 10% of pheochromocytomas are malignant. Incidentally, pheochromocytomas are called the 10% tumor because they are associated with a 10% risk of malignancy, because 10% of the tumors are bilateral, and because 10% of the tumors are extra-adrenal. Early detection may reduce the risk of metastasis.

Usually, tumors are larger than 3 cm when seen. They are highly vascular (see the images below), and larger tumors are prone to hemorrhage and necrosis, even when they are benign.

Selective adrenal angiogram demonstrates the highl

Selective adrenal angiogram demonstrates the highly vascular nature of a pheochromocytoma. Courtesy of Dr Ali Shirkhoda, William Beaumont Hospital, Michigan.

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Three-dimensional maximal-intensity magnetic reson

Three-dimensional maximal-intensity magnetic resonance angiogram clearly demonstrates a large, hypervascular right adrenal mass. Arrowheads demarcate the right renal vein. Courtesy of Dr Ali Shirkhoda, William Beaumont Hospital, Michigan.

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Failure to make the correct diagnosis can create serious risks for the patient. Early surgical removal of the adrenal gland is important to prevent complications associated with pheochromocytomas. Delay can significantly increase the risk of an adverse event. Worse, if pheochromocytoma is not considered in the diagnosis, the injection of contrast material, especially ionic contrast material, can provoke a hypertensive crisis.

Therefore, exclusion of pheochromocytoma should be part of the diagnostic evaluation in every patient with a suprarenal mass. Some authors recommend 131I-MIBG scintigraphy and/or the use of laboratory tests to confirm or rule out excessive production of catecholamines, prior to the use of invasive procedures.

Limitation of techniques

Unfortunately, the cost and lack of availability of MIBG studies restrict its use. In addition, imaging with 131I-MIBG can be time-consuming, and the technique has limited ability to provide sufficiently accurate information for surgery. Therefore, some authors recommend the use of at least 2 of the following modalities: CT scanning, MRI, and MIBG uptake studies.

CT scanning is quick and relatively inexpensive, and it offers good spatial localization. CT scan findings are not specific enough to distinguish masses caused by pheochromocytoma from other adrenal masses. Additionally, some authors report a risk of hypertensive crisis after the injection of contrast material.

MRI is more specific for pheochromocytomas than is CT scanning, but some patients cannot tolerate MRI.

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