Thursday, February 2, 2023
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Corneal Cross-Linking

Background

Corneal collagen cross-linking with Riboflavin (Vitamin B2) and long-wave UltraViolet A (UV-A) is a surgical treatment for corneal ectasia. Cross-linking (also called C3-R, CXL, CCL, and KXL) is performed to make the cornea more rigid. 

The most common corneal ectasia is keratoconus. Keratoconus has the following characteristics:

See the list below:

generally believed to be non-inflammatory, although there are numerous recent papers published suggesting that there may be an inflammatory component;

progressive corneal ectasia;

increasing irregular astigmatism;

loss of best corrected visual acuity (BCVA) and may lead to surgery;

possible scaring and hydrops (acute disruption of Descemet’s membrane in the setting of corneal ectasia);

genetic and environmental causes;

no curative treatment.

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