Tuesday, February 7, 2023

Phenytoin Level

Reference Range

Phenytoin is used as both an abortive and preventive medication in seizure management.

The total phenytoin reference range varies by age, as follows:

Children and adults: 10-20 µg/mL

Neonates: 8-15 µg/mL

Toxic phenytoin levels are defined as greater than 30 µg/mL.

Lethal levels are defined as greater than 100 µg/mL.

The reference range of free phenytoin is 1-2.5 µg/mL.

In patients with renal failure associated with hypoalbuminemia, free phenytoin levels may be more accurate than total phenytoin levels.
However, the Sheiner-Tozer formula (below) can be used to correct the phenytoin level.

Adjusted concentration = measured total concentration / [(0.2 x albumin) + 0.1]

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