Carbamazepine (Tegretol) is an iminostilbene that has been used as a first-line medication for both generalized and partial complex seizure disorders.
The therapeutic reference range of carbamazepine is 4-12 mg/L.
The minimum toxic level is 10 mg/kg.
The toxic concentration/critical laboratory value is greater than 30-40 mg/L.
The Terminal elimination half-life of carbamazepine is 18-55 hours for initial/short-term use and 5-26 hours for long-term use (3-5 weeks of continuous drug therapy). The terminal elimination half-life of 10,11-epoxide (carbamazepine metabolite) is 5-10 hours.
The volume of distribution is 1.4 L/kg (up to 3 L/kg in cases of overdose).