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Urinary Free Cortisol

Reference Range

Urinary free cortisol measurements are used primarily in the diagnosis of hypercortisolism caused by Cushing syndrome.

Reference ranges for urinary free cortisol vary by age, as follows:

Age 0-2 years – Not established

Age 3-8 years – 1.4-20 µg/24 h

Age 9-12 years – 2.6-37 µg/24 h

Age 13-17 years – 4-56 µg/24 h

Age 18 years or older – 3.5-45 µg/24 h

Conversion factor

Cortisol: µg/24 h X 2.76 = nmol/24 h (molecular weight = 362.5)

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