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HomeLaboratory MedicineBrain-Type Natriuretic Peptide (BNP)

Brain-Type Natriuretic Peptide (BNP)

Reference Range

The most important use of natriuretic peptides is in helping to establish the diagnosis of heart failure (HF) in a patient in the urgent care setting in whom the diagnosis is uncertain.

The reference values of brain-type natriuretic peptide (BNP) and N-terminal (NT) proBNP are different to exclude or confirm a diagnosis of heart failure. These values also depend on age and gender and are higher in elderly persons and women.

Normal findings are as follows

BNP: < 100 pg/mL

NT-proBNP: < 300 pg/mL

Critical value

BNP: >400 pg/mL (heart failure likely)

In patients with a prior diagnosis of heart failure, knowledge of optivolemic natriuretic peptide values is important when interpreting elevated levels of these molecules.

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