Thursday, June 8, 2023

Factor IX Assay

Reference Range

Factor IX (plasma thromboplastin component [PTC]) is produced in the liver. It is a single-chain zymogen with a molecular weight of 57 kd and a plasma half-life of 18-24 hours. It binds effectively to collagen not only in vitro
but also, apparently, in vivo, and this may account for the finding that when factor IX is infused into hemophilia B patients, recovery is only 50% of what was expected.

The reference range for factor IX is between 60% and 140% of normal values.

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