Factor VII circulates as a single-chain zymogen with a molecular weight of about 50,000 daltons. It has the shortest half-life of the procoagulant factors, approximately 3-6 hours.
The human factor VII gene is located on chromosome 13, very close to the gene for factor X.
Research indicates that embryos deficient in factor VII develop normally, without evidence of hemorrhage. Nevertheless, factor VII–deficient newborns sometimes develop fatal intra-abdominal or intracranial hemorrhage.
The reference range for factor VII is 65-140% of normal.