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Honeycomb Lung Pathology

Definition

In pathology, honeycomb lung refers to the characteristic appearance of variably sized cysts in a background of densely scarred lung tissue. Microscopically, enlarged airspaces surrounded by fibrosis with hyperplastic or bronchiolar type epithelium are present.
 However, these changes are nonspecific and are often seen in numerous end-stage interstitial lung diseases (ILDs).
 Recognition of honeycomb change is imperative as its presence is associated with a poor prognosis.

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