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Blepharitis Organism-Specific Therapy

Specific Organisms and Therapeutic Regimens

Blepharitis can be classified as anterior, posterior, or marginal (combination of anterior and posterior) blepharitis.

Anterior blepharitis is generally caused by low-grade infections, primarily with Staphylococcus epidermidis or Staphylococcus aureus, but also with Propionibacterium acnes or corynebacteria.

Posterior blepharitis is generally caused by meibomian gland dysfunction or rosacea.

Marginal blepharitis can be caused by Demodex infestation or Phthirus pubis (crab lice) infestation.

Long-term daily eyelid margin hygiene is the main treatment for blepharitis, although additional pharmacological treatments may be added for each of the various types, depending on the causative organism(s).

Warm compresses/lid hygiene

A clean wet washcloth should be heated (and frequently reheated with a microwave) to 104-110°F and rested on closed eyes directly at the eyelid margin for a minimum of 10 minutes (up to 15-20 minutes in severe cases). The heat opens the meibomian gland pores and melts the clogged oils.

With the same wash cloth, scrub the base of the eyelashes to express the meibomian glands and to remove any scurf, collarettes, and crusting.

This procedure should be repeated twice a day until the blepharitis has resolved.

Anterior blepharitis – Pharmacological treatment for staphylococcal infection

Pharmacological treatments for anterior staphylococcal blepharitis include the following:

Bacitracin ophthalmic ointment applied to lid margin qid for 1-2 weeks

Erythromycin ointment applied to lid margin qid for 1-2 weeks

Azithromycin ophthalmic drops bid for 3 days then once daily for 27 days


Tobramycin 0.3%/loteprednol etabonate 0.5% ophthalmic suspension qid in each eye for 2 weeks


Tobramycin 0.3%/dexamethasone 0.1% ophthalmic solution qid in each eye for 2 weeks

Avenova eyelid scrub (hypochlorous acid 0.01%, Nova Bay Pharmaceuticals) bid in each eye

Posterior blepharitis – Pharmacological treatment for meibomian gland dysfunction and rosacea

Pharmacological treatments for posterior blepharitis due to meibomian gland dysfunction and rosacea include the following:

Doxycycline PO 50 g/day for 3-6 months


Minocycline PO 50 mg bid for 2 months


Azithromycin PO 500 mg/day for 2 weeks

Cyclosporin ophthalmic solution bid in each eye for 1 year


Omega 3 essential fatty acids PO 1000 mg/day

Marginal blepharitis – Pharmacological treatment for Demodex infections

Pharmacological treatments for marginal blepharitis due to Demodex infections include the following:

Tea tree oil 5% daily eyelid scrub for 6 weeks

Cliradex eyelid wipe bid in each eye for 6 weeks

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