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Pathology of Pleomorphic Adenoma

Definition

Pleomorphic adenoma is a benign salivary gland tumor that exhibits wide cytomorphologic and architectural diversity. The tumor has the following 3 components:

An epithelial cell component

A myoepithelial cell component

A stromal (mesenchymal) component

Identification of these 3 components, which may vary quantitatively from one tumor to another, is essential to the recognition of pleomorphic adenoma. This tumor is also referred to as a benign mixed tumor.

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