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Pathology of Hormonal Therapy on Prostate Cancer

Overview

In this article, the pathologic effects of hormonal therapy on benign prostatic tissue and prostate cancer are presented. Hormonal therapy is the main treatment for men with disseminated prostate cancer.
In addition, hormonal therapy, also known as endocrine- or androgen-deprivation therapy, is commonly used in locally advanced or high-grade, high-risk disease. (See the image below.)

Pathology of Hormonal Therapy on Prostate Cancer.

Pathology of Hormonal Therapy on Prostate Cancer. Androgen-deprivation therapy effect on benign prostatic tissue.

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Compared with conservative management, primary androgen-deprivation therapy is not associated with improved survival in the majority of men aged 66 years or older with clinically localized prostate cancer.
Neoadjuvant hormonal therapy before radical prostatectomy has not been shown to be effective.

Molecular genetics

Molecular genetic abnormalities are not currently used in the diagnosis of prostatic carcinoma with treatment effect. Deoxyribonucleic acid (DNA) ploidy and chromosomal abnormalities are similar in treated versus untreated carcinoma,
although gene expression profiling shows that several hundred genes are differentially expressed in the comparison of untreated versus hormonally treated and androgen-independent carcinomas.

Prognosis

Grading of hormonal treatment effects (regression grading) to predict clinical outcome has been attempted but has yielded variable results. This is not routinely performed, and special studies on prostatic carcinoma with treatment effect are not currently done.

For more information on prostate cancer, see the following:

Prostate Cancer

Laparoscopic Pelvic Lymph Node Dissection in Prostate Cancer

Prostate Cancer – Radical Perineal Prostatectomy

Prostate Cancer – Radical Retropubic Prostatectomy

Prostate Cancer – Brachytherapy (Radioactive Seed Implantation Therapy)

Transrectal Ultrasonography of the Prostate

Cryotherapy in Prostate Cancer

Laparoscopic and Robotic Radical Prostatectomy

Pelvic Lymph Node Dissection

Prostate Cancer – External Beam Radiotherapy

Postradiation Therapy Pathology of Prostate Cancer

Precancerous Lesions of the Prostate

Prostate Cancer and Nutrition

Metastatic and Advanced Prostate Cancer

Neoadjuvant Androgen Deprivation Therapy in Prostate Cancer

Prostate-Specific Antigen Testing

Prostate-Specific Antigen Assays

Prostate Cancer Diagnosis and Staging

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