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Pathology of Transitional Cell Prostate Carcinoma

Overview

Transitional cell carcinoma (TCC) of the prostate is carcinoma of urothelial origin with a pathology that involves prostatic tissue. Primary prostatic TCC involves the entire prostatic urethra, particularly near the verumontanum, the large prostatic duct, and nearby acini. Secondary prostatic TCC mainly involves the bladder neck or posterior prostatic tissue; it results from direct pagetoid spread of urothelial cancer in situ (CIS) or direct pathologic invasion of bladder urothelial carcinoma.

The reported incidence of prostatic TCC ranges from 21.8-36.7%, depending mainly on the manner of examination.
Over 90% of cases are associated with bladder cancer.

Gross findings

Prostatic urethra involvement solely by CIS may not be grossly evident. Extensive involvement of the prostatic duct and acini may appear as areas of luminal necrosis and periductal fibrosis. In cases of prostatic stroma invasion, there are irregular areas of induration and fibrosis.

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