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Acute Fatty Liver of Pregnancy

Practice Essentials

Acute fatty liver of pregnancy (AFLP) is a serious complication unique to pregnancy first described by Sheehan in 1940.
 It is characterized by microvesicular steatosis in the liver. The foremost cause of AFLP is thought to be due to a mitochondrial dysfunction in the oxidation of fatty acids leading to an accumulation in hepatocytes. The infiltration of fatty acids causes acute liver insufficiency, which leads to most of the symptoms that present in this condition. If not diagnosed and treated promptly, AFLP can result in high maternal and neonatal morbidity and mortality.

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