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Thygeson Superficial Punctate Keratitis

Background

In 1950, California ophthalmologist Phillips Thygeson described multiple case reports of an unusual superficial punctate keratitis that he described as a transient, bilateral disease, having coarse corneal epithelial opacities and no associated stromal involvement.

Today, this condition is known as Thygeson superficial punctate keratitis (TSPK). It is a chronic, often bilateral, recurring illness, with relapses over years to decades. Multiple, whitish gray, intraepithelial corneal lesions, with minimal to no conjunctival involvement, are trademark characteristics of the disease.

Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology.

Artificial tears, topical corticosteroids, topical cyclosporine, and therapeutic soft contact lenses are the typical treatment methods for the disease, and the success of these treatments varies according to the severity of the disease.

Although vision may be mildly decreased during the active disease, the long-term visual prognosis is excellent.

The cornea of a 33-year-old African American man w

The cornea of a 33-year-old African American man with active Thygeson superficial punctate keratitis (TSPK).

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