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HomeOphthalmologyPosterior Polymorphous Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy

Background

First described by Koeppe, posterior polymorphous corneal dystrophy (PPMD) is a dominantly inherited condition characterized by particular alterations of the Descemet membrane and the corneal endothelium.
Typically, the corneal changes are either slowly progressive or nonprogressive. In severe cases, corneal decompensation and edema can occur. Although PPMD is most often a bilateral condition, marked asymmetry in the degree of involvement may be seen. Most persons with PPMD are asymptomatic. See the image below.

Slit lamp image demonstrates posterior corneal ves

Slit lamp image demonstrates posterior corneal vesicles and opacities in linear bands and other polymorphous configurations typical of posterior polymorphous corneal dystrophy.

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