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Asymmetric Periflexural Exanthem of Childhood


In 1962, Brunner et al reported a “new papular erythema” in 75 children aged 6 months to 5 years.
Later, in 1992, Bodemer and de Prost published a case series of 18 children and named the condition unilateral laterothoracic exanthem (ULE).
In 1993, Taieb and colleagues suggested the term asymmetric periflexural exanthem of childhood (APEC) to replace ULE, as the latter did not fully depict the morphologic distribution of the skin lesions present in this condition.
Asymmetric periflexural exanthem of childhood is classified as a rare self-limited and spontaneously resolving exanthem with unknown etiology that occurs in children.
To date, only 3 case presentations in adults have been documented.

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