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Neutrophilic Eccrine Hidradenitis

Background

Neutrophilic eccrine hidradenitis (NEH) was initially described in acute myelogenous leukemia (AML) patients undergoing chemotherapy.
Neutrophilic eccrine hidradenitis has since been reported in persons with various neoplastic and nonneoplastic conditions and in otherwise healthy individuals; however, most documented cases have continued to be observed in the setting of AML, usually in association with chemotherapy; the name toxic erythema of chemotherapy has been proposed.
It has also been associated with other drugs, including pegfilgrastim, the antiplatelet agent ticagrelor, and infliximab, as well as various infections.

Patients with this uncommon, self-limited condition usually present with fever and nonspecific cutaneous lesions. Children may develop a palmoplantar variant of neutrophilic eccrine hidradenitis unassociated with underlying disease.
 Plantar neutrophilic hidradenitis is associated with Pseudomonas overgrowth in sweaty or wet sneakers and has also been dubbed Pseudomonas hotfoot. A skin biopsy specimen demonstrating characteristic pathologic changes of the eccrine glands is required to confirm a diagnosis of neutrophilic eccrine hidradenitis.

Also see the Medscape articles Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia.

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